Associations of Hemostatic Variables with Cardiovascular Disease and Total Mortality: The Glasgow MONICA Study

Abstract The associations of plasma levels hemostatic factors, other than fibrinogen, with risks cardiovascular disease (CVD) and all-cause mortality are not well defined. In two phases the Glasgow MONICA study, we assayed coagulation factors (VII, VIII, IX, von Willebrand factor), inhibitors (antithrombin, protein C, S), activation markers (prothrombin fragment 1 + 2, thrombin–antithrombin complexes, D-dimer), fibrinolytic tissue plasminogen activator (t-PA) antigen inhibitor type 1. Over 15 to 20 years, followed up between 382 1,123 men women aged 30 74 without baseline CVD, for CVD mortality. Age- sex-adjusted hazard ratios (HRs) (top third vs bottom third) were significant only factor VIII (1.30; 95% confidence interval [CI], 1.06–1.58) IX (1.18; CI, 1.01–1.39); these HRs attenuated by further adjustment risk factors: 1.17 (95% 0.94–1.46) 1.07 0.92–1.25), respectively. contrast, (HR, 1.63; 1.35–1.96), D-dimer 2.34; 1.26–4.35), t-PA 2.81; 1.43–5.54) strongly associated after full adjustment. Further studies, including meta-analyses, required assess stroke heart causes